A case of generalized xanthogranuloma with systemic involvement

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[Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].

CASE REPORT A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study. Systemic corticosteroids and cyclosporine were initiated unsuccessfully...

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Systemic form of juvenile xanthogranuloma: report of a case with liver and bone marrow involvement.

Systemic form of juvenile xanthogranuloma with involvement of liver and bone marrow is reported in a 2-month-old female infant who presented with hepatosplenomegaly, severe anemia, and thrombocytopenia. There was no skin lesion, nor bone lesion. The enlarged liver has generalized yellowish spots. The diagnosis of juvenile xanthogranuloma was made by pathologic findings of marrow and portal trac...

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Necrobiotic xanthogranuloma with paraproteinemia without periorbital involvement—a case report

Necrobiotic xanthogranuloma is an uncommon granulomatous disease involving the skin and extracutaneous tissues. It is characterized by indurated, yellow-red plaques and nodules, involving primarily the face and less frequently the trunk and extremities. The disease has a strong association with paraproteinemia and other hematologic or lymphoproliferative disorders. Histologically, the dermal pa...

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Solitary juvenile xanthogranuloma with tibial involvement: a case report.

Juvenile xanthogranuloma (JXG) is a rare disease that is part of a spectrum of histiocytic dendritic cell disorders. Most patients present with a solitary cutaneous lesion; however, others present with extracutaneous manifestations or even with systemic involvement. We present the first report of an 11-month-old girl in whom was diagnosed a unifocal extracutaneous JXG involving the tibia. Histo...

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A multisystem granulomatous disease: necrobiotic xanthogranuloma with hepatic involvement.

Clinical record A 51-year-old woman was referred to hospital after an incidental fi nding of abnormal liver function test results (γ-glutamyl transpeptidase, 271 U/L [reference interval (RI), < 60 U/L]; alkaline phosphatase, 220 U/L [RI, 30–110 U/L]; hepatic transaminases, normal), acute renal impairment (urea, 11.7 mmol/L [RI, 2.7–8.0 mmol/L]; creatinine, 207 μmol/L [RI, 50–100 μmol/L]) and el...

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ژورنال

عنوان ژورنال: JAAD Case Reports

سال: 2019

ISSN: 2352-5126

DOI: 10.1016/j.jdcr.2019.09.018